Isoflavones can modulate chemical pathways involved in maintaining normal function and health in the prostate 2. Prostate enlargement is thought to be caused by excessive amounts of two hormones, estradiol and dihydrotestosterone (DHT) in the prostate. Estradiol is produced from testosterone by the enzyme aromatase. DHT is produced from testosterone by the enzyme 5-alpha reductase. DHT is a potent form of testosterone and binds to receptors in the prostate resulting in prostate enlargement. Trinovin acts in three ways to relieve symptoms of prostate enlargment: Stops over-activity of the enzyme 5-alpha reductase 2, reducing the amount of potent DHT in the prostate. Locks DHT out of the receptor in the prostate 9. Blocks excessive estradiol production, by inhibiting the enzyme aromatase 8. Only isoflavones act in three ways to maintain prostate health. Most other supplements, including saw palmetto work in only one way; inhibition of 5-alpha reductase.